Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
Most biochemistry labs that study DNA isolate it within a water-based solution that allows scientists to manipulate DNA without interacting with other molecules. They also tend to use heat to separate ...
How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...
Determining protein structures requires crystals, but getting proteins to crystallize has long depended on a slow, unpredictable process of trial and error ...
Scientists have long believed that large stretches of our genetic material, known as long noncoding RNAs (lncRNAs), help ...
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Flexible DNA directs proteins into atomically ordered crystals, overturning crystallization assumptions
Normally, proteins crystallize because parts of their surfaces happen to stick together through multiple weak chemical interactions. By contrast, Mirkin's team exploited DNA's natural tendency to seek ...
Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 ...
When it comes to cancer, tumor suppressor genes are usually thought of as the "good guys." These genes make proteins that protect and repair DNA in cells. If they stop functioning or there's not ...
DNA can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not properly repaired ...
Data from a new study in mice connects unrepaired DNA-protein crosslinks (DPCs), highly toxic tangles of protein and DNA, to inflammation-linked premature aging and embryonic lethality in mice. The ...
Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 ...
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