Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

Mechanisms associated with the genesis of cancer stem cell stemness, such as oxidative stress, tumor metastasis and recurrence, hypoxia induction, and tumor invasion. Genes & Diseases publishes ...

Ubiquitin is a small protein consisting of 76 amino acids that binds to lysine residues of substrates, usually by a combination of three enzymes: a ubiquitin-activating enzyme (E1, two types), a ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study ...